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Zyflamend Helps Ease The Pain And Inflammation Of Arthritis And May Possess Cancer-Fighting Properties
Like most people you've probably resorted to taking non-steroidal anti-inflammatory drugs (NSAIDs) - over-the-counter painkillers like aspirin and ibuprofen - from time-to-time, to help relieve a persistent headache or nagging toothache that just won't go away. You may even be taking them on a regular basis to alleviate a more chronic problem such as arthritis.
However, analgesics like these can cause a host of harmful side effects, including gastrointestinal disorders. What many people aren't aware of is that natural alternatives exist, which can banish pain without causing any adverse effects. Ten herbs that have been found to be particularly beneficial in this area are holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano and scutellaria.
Now, following extensive research into their individual pain-relieving properties, these 10 herbs have been combined into a new formula called Zyflamend. It has been found to offer effective relief against pain caused by inflammatory conditions such as arthritis.
Zyflamend helps put the breaks on a pain-causing mechanism in your body
Zyflamend works in a similar way to NSAIDs, killing pain by decreasing the production of pro-inflammatory prostaglandins (hormone-like substances), which are generated by the cyclooxygenase (COX) enzyme.
There are in fact two cyclooxygenase enzymes - cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 has many important functions in your cells and is continually being produced by your body. These functions include regulation of blood flow, platelet function, gastro-intestinal protection and regulation of kidney function. However, while the correct amount of COX-2 in the body is also vital for a number of biological functions, if its activity increases (often caused by an excess consumption of red meat, saturated fats and refined vegetable oils) so too does the presence of pain and inflammation.
Like NSAIDs, Zyflamend works by suppressing the effect of COX-2. Not only does this help control pain but there is also mounting evidence to suggest that this action may even protect against cancer, as raised COX-2 activity appears to increase the incidence of cancer. For example, a number of studies have found elevated levels of COX-2 in prostate cancer cells.1
In addition, COX-2 is 60 times more prevalent in a cancerous pancreas than in a normal one and the enzyme may be present in up to 90 per cent of patients suffering from rectal cancer.2
How the 10 herbs in Zyflamend work to combat pain and inflammation
The individual herbs contained in Zyflamend have each been extensively studied for their pain-relieving properties and potential anti-cancer activity. They include:
- Holy Basil. Indigenous to India, holy basil (not to be confused with common basil that is used as a culinary herb) contains ursolic acid. Research carried out at Dartmouth Medical School suggests that a strong link exists between ursolic acid's anti-inflammatory and anti-cancer actions and its ability to inhibit COX-2.3
- Turmeric. The active constituent of turmeric, a common ingredient added to curries, is a plant chemical called curcumin. It has been shown to reduce inflammation by lowering histamine levels and preventing the overproduction of COX-2. Researchers conducting a preliminary trial involving rheumatoid arthritis patients found that curcumin was beneficial in reducing inflammation, pain and stiffness.4
- Ginger also inhibits the COX-2 enzyme. According to authors Thomas M Newmark and Paul Schulick of Beyond Aspirin (HOHM Press, 2000), 'ginger not only safely modulates COX-2, but it also safely brings balance to COX-1 enzyme activity in a manner that is vastly superior to the synthetic NSAIDS, like aspirin'.
- Green Tea contains the potent COX-2 inhibitors salicylic acid and polyphenols. A 1999 study published in the US Government's Proceedings of the National Academy of Science refers to the polyphenols in green tea as having a 'marked reduction' on COX-2 induced arthritis.5 Several experiments also suggest that they possess potent anti-cancer properties, particularly for cancers of the stomach, small intestine, pancreas, colon, lung and breast.6,7,8
- Rosemary. In 1998, Swedish scientists identified the COX-2 inhibiter ursolic acid in rosemary. It also contains apigenin, which researchers at the National University of Taiwan claim to be a, 'markedly active inhibitor of COX-2'.
- Hu Zhang (Polygonum cuspidatum). This herb, which is native to Japan, is the richest known source of a polyphenol called resveratrol, which acts as a powerful antioxidant and inhibitor of COX-2.9
- Chinese Goldthread and Barberry both contain a compound called berberine that prevents excess amounts of COX-2. Besides its anti-inflammatory and anti-microbial properties, berberine has also been shown to exert an anti-cancer action in a number of studies.10
- Oregano contains four compounds - apigenin, kaempherol, ursolic acid and oleanolic acid - that have displayed COX-2 inhibiting effects.
- Scutellaria contains the flavonoid baicalein which suppresses COX-2. Korean scientists have found that scutellaria stimulates an important cancer detoxification enzyme called quinone reductase.11
In addition, researchers in Japan have demonstrated that scutellaria is able to inhibit the spread of colon cancer.12
Laboratory tests conducted at the Department of Urology, Columbia University in New York, and led by scientists Debra Bemis, PhD and Aaron Katz, MD, found that the combined herbs in Zyflamend were able to slow the growth of prostate cancer cells.13
In addition, Zyflamend also doubled the rate at which the cancerous cells self-destructed, a natural anti-cancer activity known as apoptosis or programmed cell death.
What to take for best results
The recommended dosage is one Zyflamend capsule taken twice a day with your main meal and with a glass of water.
WARNING: Women who are pregnant or trying for a baby should consult their GP before taking Zyflamend.
1. Natural cyclooxygenase inhibitors and their potential activities against prostate cancer, Columbia-Presbyterian Medical Center, Summer 2002.
2. Dr James Duke, The most important medicine you'll ever grow: COX-2 inhibitors can ease pain and fight cancer - naturally. Special report Natural Health, part two.
3. Honda, SN et al. Novel triterpenoids suppress inducible nitric oxide synthase and inducible cyclooxygenase in mouse macrophages. Cancer Res 1998;58(4):717-23.
4. Deodhar SD, Sethi R, Srimal RC. Preliminary studies on antirheumatic activity of curcumin (diferuloyl methane). Ind J Med Res 1980;71:632-4.
5. Haqqi TM, et al. prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA 1999;96(8):4524-9.
6. Mukhtar H, Ahmad N. Green tea in chemoprevention of cancer. Toxicol Sci 1999;52(2 Suppl):111-7.
7. Katiyar SK, Mukhtar H. Tea consumption and cancer. World Rev Nutr Diet 1996;79:154-84 [review].
8. Kohlmeier L, Weterings KG, Steck S, Kok FJ. Tea and cancer prevention: an evaluation of the epidemiologic literature. Nutr Cancer 1997;27:1-13 [review].
9. Thomas M Newmark and Paul Schulick, Beyond Aspirin, HOHM Press 2000.
10. Fukuda K, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66(2):227-33.
11. Park HJ, et al. induction of quinone reductase by a methanol extract of scutellaria baicalensis and its flavonoids in murine hepa 1c1c7 cells. Eur J Cancer Prev 1998;7(6):465-71.
12. Fukutake M, et al. Inhibitory effect of coptidis rhizoma and scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Boil Pharm Bull 1998;21(8):814-7.
13. Bemis DL, Katz AE et al. Zyflamend, An herbal COX-2 inhibitor with in vitro anti-prostate-cancer activity. Center for Holistic Urology, Department of Urology, Columbia University, New York.
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