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Cancer
Cruciferous Vegetables Lower Your Risk Of Bladder Cancer
Date: 11/06/07
Increasing your intake of cruciferous vegetables may slash your risk of bladder cancer by up to 30 per cent according to new research, which lays the benefits at the feet of their isothiocyanate content.
Epidemiological and animal studies have shown that diets high in cruciferous vegetables result in less instances of certain cancers especially lung, colon, breast and ovarian cancer but no study until now has reported on the risk reductions against bladder cancer.
Bladder cancer is diagnosed in about 336,000 people every year worldwide, and is three times more likely to affect men than women, according to the European School of Oncology.
Assessing the results
The new study, carried out at the University of Texas M.D. Anderson Cancer Center in the US, investigated the potential of dietary isothiocyanates to reduce the risk of bladder cancer. Diets were assessed using epidemiologic and food frequency questionnaires for 697 newly diagnosed bladder cancer cases and 708 healthy controls matched by age, gender and ethnicity.
The researchers found that the average daily intake of isothiocyanates was significantly lower in those with bladder cancer than for the healthy control subjects.
The highest intake of isothiocyanates was associated with a 29 per cent reduction in bladder cancer risk compared to the lowest intake, said lead researcher Hua Zhao and his co-workers, with greater protection also observed in subjects over 64 years of age, men, and smokers.
The researchers suggest that the protective effects of the isothiocyanates against bladder cancer may be due to the increased exposure of the organ to the compounds - the majority of compounds produced by isothiocyanate metabolism are excreted through the urine.
The cancer-fighting properties of broccoli, a member of the cruciferous family of vegetables, are not new and previous studies have related these benefits to the high levels of active plant chemicals called glucosinolates. These are metabolised by the body into isothiocynates, and evidence suggests these are powerful anti-carcinogens. The main isothiocynate from broccoli is sulforaphane.
Back to topEpidemiological and animal studies have shown that diets high in cruciferous vegetables result in less instances of certain cancers especially lung, colon, breast and ovarian cancer but no study until now has reported on the risk reductions against bladder cancer.
Bladder cancer is diagnosed in about 336,000 people every year worldwide, and is three times more likely to affect men than women, according to the European School of Oncology.
Assessing the results
The new study, carried out at the University of Texas M.D. Anderson Cancer Center in the US, investigated the potential of dietary isothiocyanates to reduce the risk of bladder cancer. Diets were assessed using epidemiologic and food frequency questionnaires for 697 newly diagnosed bladder cancer cases and 708 healthy controls matched by age, gender and ethnicity.
The researchers found that the average daily intake of isothiocyanates was significantly lower in those with bladder cancer than for the healthy control subjects.
The highest intake of isothiocyanates was associated with a 29 per cent reduction in bladder cancer risk compared to the lowest intake, said lead researcher Hua Zhao and his co-workers, with greater protection also observed in subjects over 64 years of age, men, and smokers.
The researchers suggest that the protective effects of the isothiocyanates against bladder cancer may be due to the increased exposure of the organ to the compounds - the majority of compounds produced by isothiocyanate metabolism are excreted through the urine.
The cancer-fighting properties of broccoli, a member of the cruciferous family of vegetables, are not new and previous studies have related these benefits to the high levels of active plant chemicals called glucosinolates. These are metabolised by the body into isothiocynates, and evidence suggests these are powerful anti-carcinogens. The main isothiocynate from broccoli is sulforaphane.
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