Digestive Problems

Irritable Bowel Syndrome: In Just 4 Weeks, You Can Decrease the Severity and Number of Irritable Bowel Syndrome (IBS) Attacks By Up To 90% with Lp299v

Date: 5 December, 2001

According to The IBS Network, a national charity that offers information and advice on irritable bowel syndrome (IBS), the condition affects a third of the UK population at one time or another. In fact, the problem has become so common these days that about one in 10 people suffer symptoms bad enough to make them go to their doctor.
IBS symptoms can include abdominal pain and spasm, diarrhoea, constipation, bloated stomach and wind. Stress is believed to be a significant trigger factor, while recent research has confirmed that in some people, irritable bowel syndrome may be due to food intolerance.1 Other research suggests the problem may be caused by parasites or Candida (yeast) overgrowth.2

Medical treatments vary from advice on diet and relaxation to the use of anti-spasmodic drugs or bulking agents. Some people turn to complementary medicine for help, such as nutritional therapy or homeopathy, while others educate themselves about their ailment from the many books and magazine articles on the subject.

Claire Williams, 45, from London, has suffered from irritable bowel syndrome for over five years. After trying all kinds of remedies, she read about Lactobacillus plantarum 299v, a new product available from health food stores by a company called Quest Vitamins.

After a couple of months on the product her alternating constipation and diarrhoea began to ease, and her abdominal cramps subsided completely.

Claire says, IBS was making my life a misery but after discovering Lactobacillus plantarum 299v I had renewed hope for a cure. Within a matter of weeks of taking the product my symptoms improved and I now feel ecstatic that I can lead a normal life again. I even treated myself to a few takeaways over the weekend without having any trouble, something I havent done in years.


Decrease the severity of your symptoms by as much as 90%

Lactobacillus plantarum 299v or Lp299v, is a member of the Lactobacillus family of micro-organisms friendly bacteria that have been found to populate a healthy human gastrointestinal tract. A lack of healthy bacteria in the intestines can cause an overgrowth of less beneficial bacteria, and this imbalance has been linked with diarrhoea, IBS and other gastrointestinal complaints.

Lp299v differs from other Lactobacillus species because it has been extensively researched for its use in treating digestive disorders, in particular, irritable bowel syndrome. Studies show that Lp299v may decrease the frequency and severity of symptoms experienced by irritable bowel syndrome sufferers by up to 90 per cent.

In one study, 40 IBS patients were split into two groups. One group received Lp299v daily for four weeks, while the other group received a placebo. The results showed that all patients treated with Lp299v reported resolution of their abdominal pain compared to only 11 patients in the placebo group. There was also a trend towards the normalisation of stool frequency in constipated patients in six out of 10 patients treated with Lp299v compared with two out of 11 treated with the placebo. With regards to all IBS symptoms, an improvement was noted in 95 per cent of patients in the Lp299v group compared to 15 per cent of patients in the placebo group.3 

In another study, 50 IBS patients took Lp299v (plus another friendly bacteria called Bifidobacterium breve) or a placebo for four weeks. The pain score in different abdominal locations in the probiotics group decreased by 38 per cent compared to 18 per cent in the placebo group after 14 days and by 52 per cent compared to 11 per cent after 28 days.4


Lp299v works by creating a protective barrier against harmful bacteria.

Lp299v is thought to help irritable bowel syndrome sufferers because it has the ability to temporarily colonise the lining of the intestines and form a physical barrier against pathogenic bacteria.

Over time, consuming sugars, processed foods and alcohol can inhibit the friendly bacteria in the gut. Antibiotics can also damage bowel microflora. Re-colonising the intestines with Lp299v can help prevent gastrointestinal problems like IBS by depriving pathogenic bacteria of the opportunity to overgrow and flourish.

A liquid culture containing a bacteriocin (a compound produced by probiotics which helps prevent the growth and development of pathogenic bacteria), produced by Lp299v, was shown to help inhibit the growth of Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella pneumoniae and Escherichia coli. All of these bacteria have the potential to cause harm to the intestines.5

Friendly bacteria like Lp299v play an important role in the manufacture of short-chain fatty acids in the body. One of these fatty acids butyric acid feeds the epithelial mucosa cells lining the gut wall and is essential in maintaining the integrity of the gastrointestinal wall. The manufacture of short-chain fatty acids also helps maintain a slightly acid pH level in the gut, which in turn promotes the growth of acid loving beneficial bacteria such as Lactobacillus.

After surviving stomach acid, it arrives in your large intestine
ready to go to work

Another reason for Lp299vs effectiveness could be that it is one of the few types of friendly bacteria supplements that have been shown to survive the journey through the acid environment of the stomach, and to reach the large intestine where it is able to establish itself and flourish for days.

To be effective, a probiotic supplement must survive the passage through the stomach to be viable on arrival at the large intestine. The presence of friendly bacteria in the faeces is therefore evidence that the probiotic has survived the harsh acidic environment of the stomach.

In a study that looked at the resistance of Lp299v, 22 participants consumed a fermented oatmeal drink with or without Lp299v for four weeks. Lp299v significantly increased the number of Lactobacilli in the stools of the test group within one week, therefore proving that this strain of bacteria is highly resistant to stomach acid.6


What to take for best results

The recommended dose is one capsule twice daily on an empty stomach.

Contraindications: There are no known contraindications associated with Lp299v and it is safe to take during pregnancy and breastfeeding. The use of antibiotics may deplete friendly bacteria in the gut, therefore, antibiotics and Lp299v should be taken at least two hours apart.

1. Gut 2004; 53(10): 1459-64
2. Franklin, Michael. An overview of Comprehensive Digestive Stool Analysis results from The IBS and Gut Disorder Centre. 2002-2005
3. Eur J Gastroenterol Hepatol 2001; 13(10): 1143-7
4. J Clin Gastroenterol. 2004; 38(6 Suppl): S104-6
5. J Gen Appl Microbiol 2004; 50(3): 149-57
6. Int J Food Microbiol 1998; 42: 29-38

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  1. Mara Posted February 1, 2016

    LP299v saved my life, I don’t know why I did not find out about this product sooner. for the first time in my life I found something that does exactly what it promises to do. It Works…

  2. LLEWELYN WEWEGE Posted October 28, 2015

    Just started using the product will monitor the success

  3. Nguatenge Posted December 6, 2010

    i have used lp299v for a month and all IBs symptoms subsided, even had geographic tongue, oral thrush and all cleared thumbs up to this mirracle!!! only prob is its expensive . is there any generic product for LP299v??

  4. adel Posted July 17, 2010

    Im using LP299v for 10 days now and already feel so much better!!!!;-))

  5. Vanessa Posted April 22, 2010

    I have tried this for a few days and my cramps are gone, but have had no bowel movement at all. What should I do?

  6. ROSEMARY TUBBS Posted July 15, 2009

    LP299v – truly amazng. Have had IBS for several years – very debilitatng condition. Blood tests revealed no allergy – likelihood of causation stress/anxiety. I tried various remedies but this little cap seems to be the answer after only 10 days of use I can honestly say a 90 per cent improvement thanks to you and Quest.

  7. altaf Posted December 29, 2008

    i start from 2day lets see what happen , i have uc problems , i am taking asacol also,i have uc problems from last 10 yrs,

  8. finger crossed Posted November 9, 2008

    just started taking lp299v. all i want a normal life lets hope it will cure ibs.

    finger crossed!

  9. Mike Angelo Posted August 27, 2008

    I have found a stockist near me. I shall be purchasing this on Thursday (when I get paid), so expect me on here a few months down the line to report my findings.

  10. Sexy_sapphire Posted August 20, 2008

    I am suffering from IBS for a while now,I guess there is no harm in trying this product,Thank you for a wonderful site.

  11. Ebrahim Ali Posted July 16, 2008

    I am an ulcerative colitis sufferer for three years and relapsed a year ago. My condition was worsening until I tried Lp299V recommended by a pharmicist not a Gastroentorologist. I have been on this together with Asacol for three weeks now and I already am normalised to 2 bowel movements a day. Please also trial this product with UC sufferers as it may eventually lead to a cure, it seems to have worked miracles for me. Will keep my comments updated for the next few months to see if it remains this way.

  12. Maureen Hardick Posted May 30, 2008

    I have been suffering from ibs for years and have now started using LP299V

  13. kooben pillay Posted May 19, 2008

    i have been taking LP299v for 5 months and it has saved my life! I no longer have cramps or pain in my stomache and I lead a relatively normal life, I also dont get sick with the common cold or flu or other minor aliments. Could this be attributed to the LP299v?

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