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The Best Way to Administer CoQ10
Co-enzyme Q10 (CoQ10) is definitely the rising star of antioxidants. There is an ever-growing body of scientific data that shows substantial health benefits of CoQ10 supplementation for people suffering from angina, heart attack and hypertension. Clinical trials have also reported benefits for cardiomyopathy (heart muscle disease ) and congestive heart failure.
Researchers from Canada has compared CoQ10 formulas in hard and soft gel capsules, and found the reduced form in soft gel capsules resulted in 3.3-times higher blood level of CoQ10 than those in hard gel capsules.
Details of the study
The small study, which included only 10 subjects used a single-centre, double-blind, randomized two-arm crossover design.
Lead researcher Malkanthi Evans assigned the volunteers to receive either a single 100 mg of the commercial CoQ10 formula in a hard capsule or the reduced CoQ10 in a soft gel capsule.
Blood concentrations of CoQ10 showed that higher blood levels were monitored after intake of the reduced co-enzyme at five, six, eight, 12, 24, 48 and 72 hours. The result was a 430 per cent increase in levels being recorded in the volunteers receiving the reduced form, compared to volunteers receiving the standard commercial form, said the researchers.
Why is this study important?
The formulation of the CoQ10 is known to play a key role in its bioavailability.
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the blood stream. When a medication is administered intravenously, its bioavailability is 100 per cent. However, when a medication is administered via other routes (such as orally), its bioavailability decreases (due to incomplete absorption and metabolic factors).
Since the CoQ10 is lipophilic (fat-loving) its absorption is enhanced in the presence of lipids (fat). Therefore, when taken as a supplement apart from meals, the absorption of some formulas can be lower.
Trials with CoQ10 supplements in powder and oil-suspension forms are reported to result in small or negligible bioavailability.
The researchers said: “In the current study, both formulations studied were presented as capsules; however, [the reduced form] was formulated using reduced CoQ10 with stabilizing ingredients in a soft gel capsule compared to the typical commercial formulations... It can be inferred that the product maintained integrity leading to an increased rate of absorption, resulting in greater bioavailability.”
Chemistry of CoQ10
CoQ10 has properties similar to vitamins, but since it is naturally synthesized in the body it is not classed as a vitamin. It is also known as ubiquinone because of its 'ubiquitous' distribution throughout the human body.
CoQ10 is stored in the mitochondria - the 'power plants' of the cell - and plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body's co-called 'energy currency'.
With CoQ10 also acting as a potent antioxidant, the coenzyme plays an important role in preserving levels of vitamin E and vitamin C.
Commercially most variations of CoQ10 are only available in powder or oil-suppression forms; however, by doing careful research it is possible to find CoQ10 in a soft gel, liquid form at health food stores. Since this antioxidant can be quite costly it is best to do your homework before forking out some hard-earned cash for something that can be a tremendous health benefit – but only if taken in the right formula.
Related articles:
Co-enzyme Q10 Helps Your Body Recover Following Strenuous Exercise
Statins: Safe and natural alternatives to cholesterol drugs
ActivLife Q10 Is 8 Times More Effective Than Ordinary Co-Enzyme Q10
Sources:
"A randomized, double-blind trial on the bioavailability of two CoQ10 formulations", published by Journal of Functional Foods, January 2009, Volume 1, Issue 1, Pages 65-73, Authors: M. Evans, J. Baisley, S. Barss, N. Guthrie
‘6 Reasons to eat Blueberries’, published online, drweil.com
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