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Heart Disease
Co-enzyme Q10 For a Healthy Heart
A recent randomised, double-blind, placebo controlled trial has confirmed Coenzyme Q10s heart healthy benefits.
Researchers found that supplementation with CoQ10 helps boost naturally-occurring antioxidant enzymes and endothelial function in patients with coronary artery disease (CAD).
Coronary artery disease (CAD) is a blockage of the vessels which supply your heart with blood.
Assessing the results
The study, led by Luca Tiano from Italy's Polytechnic University of the Marche, divided 38 CAD patients into two groups, with one receiving 100 mg/d of CoQ10 and the other a placebo for one month.
CAD reduces extracellular superoxide dismutase (ecSOD) a major antioxidant enzyme system of blood vessel walls. However, the CoQ10-supplemented group had more ecSOD at the end of the trial than the placebo group.
Tiano stated that the coenzyme also boosted endothelial function. She said: 'The data from our group highlighted that CoQ10 greatly attenuates the endothelial dysfunction in patients affected by ischaemic heart disease.'
The researchers found that the improvements were particularly significant in patients with low initial endothelium-bound ecSOD, who were more prone to oxidative stress.
ecSOD activity raised from 17.3+1.7 to 22.4+1.3 U/mL/min in the treated group, whereas there was only a slight change in the placebo group, from 16.6+1.6 to 17.3+1.6 U/mL/min.
Commenting on the findings the researchers said: 'The results of the present investigation indicate that the oral CoQ10 supplementation in CAD patients has beneficial effects, which can be ascribed either to the bioenergetic role of the quinone or to its antioxidant properties.
Moreover, recent data from our group demonstrated that the CoQ10 administration improves cardiac contractility in ischaemic heart disease patients, measured by low dobutamine stress echocardiography.'
'Although the effect of CoQ10 on the ED relaxation has already been shown in patients with type II diabetes and ischaemic heart disease, the effect of CoQ10 on raising ecSOD levels represents a novel observation.'
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