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Liver, Kidney & Urinary
D-Mannose: Eliminate Recurring Urinary Tract Infections
Date: 19/03/04
Some new research helps reveal the reason why Urinary Tract Infections (UTIs) can be so irritating and hard to get rid of.
In a recent issue of the journal Science, US researchers at the Washington University (WU) School of Medicine in St. Louis explain that when Escherichia coli (E. coli) bacteria invade the bladder, they penetrate a protective coating of the superficial cells that line the bladder. Once the E. coli is established in the bladder lining, the stage is set for infection.
The WU team used mice to study bladder reaction to inoculations of E. coli. They found that after the bacteria began multiplying in the bladder lining, they formed pod structures that were protected by the cell coating. As the pods developed, they created special fibres that held them firmly in place below the coating. This type of cell organisation is called biofilm.
One of the authors of the study, Dr Joseph J. Palermo, compared the pods beneath the coating to eggs protected by an egg carton.
The researchers found that after an infection was treated with antibiotics, pods that survived the treatment soon released bacteria to begin a new infection. Dr. Palermo and his colleagues believe that theirs' is the first study to reveal disease-causing biofilms that proliferate inside cells. They also believe that this explains why many bladder infections are often followed by subsequent infections after an initial successful treatment.
Location, location, location
Clearly, we're up against some very clever E. coli. So... what to do?
Many women know that when the first signs of a bladder infection appear, a few quarts of cranberry juice can sometimes head the problem off at the pass. According to US physician DR Jonathan V. Wright, the ingredient in cranberry juice that makes it effective is the bacteria-fighting sugar: D-mannose.
D-mannose... has the ability to detach E. coli from the walls of the bladder without upsetting the balance of the friendly bacteria necessary for good health. After being loosened from bladder walls, the bacteria are rinsed away by normal urination. The E. coli aren't killed; they're simply relocated - 'from the inside to the outside' - and the infection is gone.
Cranberry... without the cocktail
But before you run out to stock up on cranberry juice, you should know that Dr. Wright says there's not really enough D-mannose in the juice to be significantly effective. Plus, the extra sugar that comes with most brands of cranberry juice just creates other unneeded problems.
Fortunately, D-mannose is available from many health food stores. Dr. Wright says that almost any bladder infection caused by E. coli can be eliminated with 1/2 to 1 teaspoonful of D-mannose, dissolved in water and taken every 2 to 3 hours.
And there's no need to worry about the sugar aspect of D-mannose; it's a simple sugar, so very little of it is metabolised by the body. Large doses are washed away in the urine, and the amounts not excreted into the urine are so small that they do not affect blood sugar levels - even in diabetics.
Judging from the Washington University study, it is a good idea to continue the treatment for a few days to continue fighting any remaining bacteria that the E. coli pods might try to reintroduce in the bladder.
Back to topIn a recent issue of the journal Science, US researchers at the Washington University (WU) School of Medicine in St. Louis explain that when Escherichia coli (E. coli) bacteria invade the bladder, they penetrate a protective coating of the superficial cells that line the bladder. Once the E. coli is established in the bladder lining, the stage is set for infection.
The WU team used mice to study bladder reaction to inoculations of E. coli. They found that after the bacteria began multiplying in the bladder lining, they formed pod structures that were protected by the cell coating. As the pods developed, they created special fibres that held them firmly in place below the coating. This type of cell organisation is called biofilm.
One of the authors of the study, Dr Joseph J. Palermo, compared the pods beneath the coating to eggs protected by an egg carton.
The researchers found that after an infection was treated with antibiotics, pods that survived the treatment soon released bacteria to begin a new infection. Dr. Palermo and his colleagues believe that theirs' is the first study to reveal disease-causing biofilms that proliferate inside cells. They also believe that this explains why many bladder infections are often followed by subsequent infections after an initial successful treatment.
Location, location, location
Clearly, we're up against some very clever E. coli. So... what to do?
Many women know that when the first signs of a bladder infection appear, a few quarts of cranberry juice can sometimes head the problem off at the pass. According to US physician DR Jonathan V. Wright, the ingredient in cranberry juice that makes it effective is the bacteria-fighting sugar: D-mannose.
D-mannose... has the ability to detach E. coli from the walls of the bladder without upsetting the balance of the friendly bacteria necessary for good health. After being loosened from bladder walls, the bacteria are rinsed away by normal urination. The E. coli aren't killed; they're simply relocated - 'from the inside to the outside' - and the infection is gone.
Cranberry... without the cocktail
But before you run out to stock up on cranberry juice, you should know that Dr. Wright says there's not really enough D-mannose in the juice to be significantly effective. Plus, the extra sugar that comes with most brands of cranberry juice just creates other unneeded problems.
Fortunately, D-mannose is available from many health food stores. Dr. Wright says that almost any bladder infection caused by E. coli can be eliminated with 1/2 to 1 teaspoonful of D-mannose, dissolved in water and taken every 2 to 3 hours.
And there's no need to worry about the sugar aspect of D-mannose; it's a simple sugar, so very little of it is metabolised by the body. Large doses are washed away in the urine, and the amounts not excreted into the urine are so small that they do not affect blood sugar levels - even in diabetics.
Judging from the Washington University study, it is a good idea to continue the treatment for a few days to continue fighting any remaining bacteria that the E. coli pods might try to reintroduce in the bladder.
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